The histone antibody blood test is a type of blood test that measures the levels of antibodies against histones in the blood. Histones are proteins that help package and organize DNA in the nucleus of cells. Antibodies against histones can be present in individuals with certain autoimmune diseases, such as systemic lupus erythematosus (SLE).

The test is performed by taking a blood sample from a vein in the arm, and then measuring the levels of histone antibodies in the blood. Elevated levels of histone antibodies can indicate the presence of an autoimmune disease, such as SLE, although other conditions can also cause elevated levels.

The test is often performed as part of a panel of tests used to diagnose autoimmune diseases, along with other tests such as the antinuclear antibody (ANA) test and the anti-double stranded DNA (dsDNA) test.

Interpretation of the test results should be done in consultation with a healthcare provider who can interpret the results in the context of the individual’s symptoms, medical history, and other test results.

In summary, the histone antibody blood test is a blood test that measures the levels of antibodies against histones in the blood. Elevated levels can indicate the presence of an autoimmune disease, such as SLE, but interpretation of the test results should be done in consultation with a healthcare provider.